![Watch Oprah ‘Sign-Off’ Of Her Show After 25 Years [VIDEO]](http://townsquare.media/site/34/files/2011/05/Screen-shot-2011-05-27-at-11.07.44-AM.png?w=980&q=75)
Watch Oprah ‘Sign-Off’ Of Her Show After 25 Years [VIDEO]
Perhaps the most anticipated day in daytime television came this week when Oprah Winfrey signed-off of the Oprah Winfrey Show. After 25 years, Oprah has decided to give up the stage, and pursue other interests in her life and career.